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In advanced ovarian cancer, malignant cells shed off the ruptured ovarian tumour into the peritoneum forming 3D cellular aggregates in order to survive and establish secondary growth on the abdominal wall of internal organs. New targeted approaches are essential to improve the survival and quality of life for patients with this disease. Ovarian cancer is a leading cause of mortality in gynaecological cancer in New Zealand and worldwide. KEY WORDS: Fetal ovary, histology, ovarian follicles. Pre-antral and 1 to 2 antral follicles were found at cortico-medullary junction.Ĭonclusion: The present study concludes the presence of capsule at 18th week, primordial folliclesat 20th week, atĢ6th week primary follicles, at 32nd week secondary follicles and at 34th week antral follicles. At the 34th week of gestation the antral follicles started appearing.
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At the 32nd week of gestation the multilayered (secondary) follicles startedĪppearing. At the 30th week of gestation cortico-medullaryĭifferentiation was clearly visible. At the 28th week of gestation many primordialĪnd primary follicles were seen near cortico-medullary junction. At the 26th week of gestation primary follicles wereĬlearly seen and the cortico-medullary differentiation was visible. Of gestation cortico-medullary differentiation was started. At the 20th week of gestation presence of primordial follicles were observed. Results: At the 18th week of gestation the microscopic structure of fetal ovary showed capsule, numerous ovigerousĬords and oogonia. The ovarian sections were observed for lining epithelium, ovagirous cords, cortico-medullaryĭifferentiation and different stages of follicles by observing their structural architecture. The ovaries were processed for histological studies by fixing, embedding, section cutting, stainingīy standard methods. The ovaries separated from uterus, weighed, the length and breadth of the ovaries were measured with The fetuses were dissected and the ovaries were removed along with the Materials and Methods: A total of twenty six human female fetuses of different age from 18th to 36th gestational The present study was planned to study the gross and histological structure of human fetal ovary at The ovaries being development, differentiation, follicular growth and stroma are indicators of reproductiveĬapability. Initiate meiosis and eventually form the life time reserve of primordial follicles. Background: The fetal life is a critical period in female fertility in which the germ cells complete proliferation,